Our Publications

CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage

CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage

The computed tomography angiography (CTA) spot sign is a validated predictor of hematoma expansion and poor outcome in supratentorial intracerebral hemorrhage (ICH), but patients with brainstem ICH have typically been excluded from the analyses. We investigated the frequency of spot sign and its relationship with hematoma expansion and outcome in patients with primary pontine hemorrhage (PPH).

January, 2016  View on PubMed  Download Article PDF 
 

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes.

December, 2015  View on PubMed  Download Article PDF 
 

Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage

Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is the most severe form of stroke. Survivors are at high risk of recurrence, death, and worsening functional disability.  The goal of this study is to investigate the association between blood pressure (BP) after index ICH and risk of recurrent ICH.

September, 2015  View on PubMed  Download Article PDF 
 

Rare Coding Variation and Risk of Intracerebral Hemorrhage

Rare Coding Variation and Risk of Intracerebral Hemorrhage

Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage.  A meta-analyses of single-variant and gene-based association were computed.

August, 2015  View on PubMed  Download Article PDF 
 

APOE ε4 and lipid levels affect risk of recurrent nonlobar intracerebral hemorrhage

APOE ε4 and lipid levels affect risk of recurrent nonlobar intracerebral hemorrhage

Genetic variants ε2/ε4 within the APOE gene are established risk factors for lobar intracerebral hemorrhage (ICH). Published preliminary data suggest a potential role for APOE ε4 in risk of nonlobar ICH. We therefore investigated the role of APOE in recurrent nonlobar ICH, and sought to clarify whether effects of APOE on circulating lipids mediate this association.

July, 2015  View on PubMed  Download Article PDF 
 

Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association

Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association

The purpose of this document is to serve as a resource for practitioners in cardiovascular and stroke medicine on the application of genetics and genomics to patient care. Although not exhaustive, it contains an overview of the field written specifically to be accessible and relevant to practitioners. It also refers to additional educational materials available in the literature, in textbooks, and on the Internet.

February, 2015  View on PubMed  Download Article PDF 
 

Recommendations from the international stroke genetics consortium, part 1: standardized phenotypic data collection

Recommendations from the international stroke genetics consortium, part 1: standardized phenotypic data collection

Majersik JJ, Cole JW, Golledge J, Rost NS, Chan YF, Gurol ME, Lindgren AG, Woo D, Fernandez-Cadenas I, Chen DT, Thijs V, Worrall BB, Kamal A, Bentley P, Wardlaw JM, Ruigrok YM, Battey TW, Schmidt R, Montaner J, Giese A, Roquer J, Jiménez-Conde J, Lee C,, Ay H, Martin JJ, Rosand J, Maguire J on behalf of theInternational Stroke Genetics Consortium. Recommendations from the international stroke genetics consortium, part 1: standardized phenotypic data collection. Stroke. 2015 Jan;46(1):279-84. PMID: 25492903; PMCID: PMC4465378.

January, 2015  View on PubMed 
 

Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage

Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage

Battey T, Valant V, Kassis SB, Kourkoulis C, Lee C, Anderson CD, Falcone GJ, Jimenez-Conde J, Fernandez-Cadenas I, Pare G, Rundek T, James ML, Lemmens R, Lee TH, Tatlisumak T, Kittner SJ, Lindgren A, Mateen FJ, Berkowitz A, Holliday EG, Majersik J, Maguire J, Sudlow C, Rosand J on behalf of the International Stroke Genetics Consortium. Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage. Stroke. 2015 Jan;46(1):285

January, 2015  View on PubMed 
 

CT Angiography Spot Sign in Intracerebral Hemorrhage Predicts Active Bleeding During Surgery

CT Angiography Spot Sign in Intracerebral Hemorrhage Predicts Active Bleeding During Surgery

Brouwers B, Raffeld M, van Nieuwenhuizen K, Falcone G, Ayres A, McNamara K, Schwab K, Romero J, Velthuis B, Viswanathan A, Greenberg S, Ogilvy C, van der Zwan A, Rinkel G, Goldstein J, Klijn C, Rosand J. CT Angiography Spot Sign in Intracerebral Hemorrhage Predicts Active Bleeding During Surgery. Neurology 2014, Sep 2;83(10):883-9. PMID: 25098540; PMCID: PMC4153853.

September, 2014  View on PubMed 
 

Meta-Analysis of Genome-Wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.

Meta-Analysis of Genome-Wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.

Woo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, Anderson CD, Brouwers HB, Valant V, Battey TW, Radmanesh F, Raffeld MR, Baedorf-Kassis S, Deka R, Woo JG, Martin LJ, Haverbusch M, Moomaw CJ, Sun G, Broderick JP, Flaherty ML,  Martini SR, Kleindorfer DO, Kissela B, Comeau ME, Jagiella JM, Schmidt H, Freudenberger P, Pichler A, Enzinger C, Hansen BM, Norrving B, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Roquer J, Kraft P, Ayres AM, Schwab K, McCauley JL, Pera J, Urbanik A, Rost NS, Goldstein JN,
Viswanathan A, Stögerer EM, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Malik R, Dichgans M, Greenberg SM, Rothwell PM, Lindgren A, Slowik A, Schmidt R,  Langefeld CD, Rosand J; International Stroke Genetics Consortium. Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for  intracerebral hemorrhage. Am J Hum Genet. 2014 Apr 3;94(4):511-21. doi: 10.1016/j.ajhg.2014.02.012. Epub 2014 Mar 20. PubMed PMID: 24656865; PubMed
Central PMCID: PMC3980413.

April, 2014  View on PubMed  Download Article PDF 
 

Anxiety and depression symptoms among families of adult intensive care unit survivors immediately following brief length of stay

Anxiety and depression symptoms among families of adult intensive care unit survivors immediately following brief length of stay

Hwang DY, Yagoda D, Perrey HM, Tehan TM, Guanci M, Ananian L, Currier PF, Cobb JP, Rosand J. Journal Critical Care 2014; 29(2):278-282. PMID: 24411107.

April, 2014 
 

Assessment of satisfaction with care among family members of survivors in a neuroscience intensive care unit

Assessment of satisfaction with care among family members of survivors in a neuroscience intensive care unit

Hwang DY, Yagoda D, Perrey HM, Tehan TM, Guanci M, Ananian L, Currier PF, Cobb JP, Rosand J. Journal of Neuroscience and Nursing 2014; 46(2):106-116. PMID: 24556658; PMCID: PMC4401420.

April, 2014 
 

Consistency of communication among intensive care unit staff as perceived by family members of patients surviving to discharge

Consistency of communication among intensive care unit staff as perceived by family members of patients surviving to discharge

Hwang DY, Yagoda D, Perrey HM, Tehan TM, Guanci M, Ananian L, Currier PF, Cobb JP, Rosand J. Journal of Critical Care 2014; 29(1):134-138. PMID: 24475496.

February, 2014 
 

Burden of Blood Pressure-Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage.

Burden of Blood Pressure-Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage.

Falcone GJ, Biffi A, Devan WJ, Brouwers HB, Anderson CD, Valant V, Ayres AM, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Rosand J. Burden of Blood Pressure-Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage. Stroke 2013;44(2):321-6. PMID: 23321443; PMCID: PMC3560332

February, 2013  View on PubMed  Download Article PDF 
 

Apolipoprotein E genotype is associated with CT angiography spot sign in lobar intracerebral hemorrhage

Brouwers HB, Biffi A, Ayres AM, McNamara KA, Ayres AM, Valant V, Schwab K, Romero JM,  Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. Apolipoprotein E genotype is associated with CT angiography spot sign in lobar intracerebral hemorrhage. Stroke. 2012 Aug;43(8):2120-5. PMID: 22621984; PMCID: PMC3426364.

August, 2012  View on PubMed  Download Article PDF 
 

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

The International Stroke Genetics Consortium (ISGC) and Wellcome Trust Case Control Consortium 2 (WTCCC2). Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nature Genetics 2012;44(3):328-333. PMID: 22306652; PMCID: PMC3303115.

February, 2012  View on PubMed  Download Article PDF 
 

Statin use and outcome after intracerebral hemorrhage: Case-control study and meta-analysis

Statin use and outcome after intracerebral hemorrhage: Case-control study and meta-analysis

Biffi A, Devan WJ, Anderson CD, Ayres AM, Schwab K, Cortellini L, Viswanathan A, Rost NS, Smith EE, Goldstein JN, Greenberg SM, Rosand J. Statin use and outcome after intracerebral hemorrhage: Case-control study and meta-analysis. Neurology 2011, May 3;76(18):1581-8. PMID: 21451150; PMCID: PMC3100126.

May, 2011  View on PubMed  Download Article PDF 
 

The effect of survival bias on case-control genetic association studies of highly lethal diseases

Anderson CD, Nalls MA, Biffi A, Greenberg SM, Singleton AB, Meschia JF, Rosand J. The effect of survival bias on case-control genetic association studies of highly lethal diseases. Circ Cardiovasc Genet 2011; 4(2): 188-196. PMID: 21292865. PMCID: PMC3080449

April, 2011  View on PubMed  Download Article PDF 
 

Principal-component analysis for assessment of population stratification in mitochondrial medical genetics

Biffi A, Anderson CD, Rahman R, Nalls MA, Cortellini L, Rost NS, Plourde A, Sonni A, de Bakker PIW, Ross O, Greenberg SM, Furie KL, Meschia JF, Singleton AB, Saxxena R, Rosand J. Principal-component analysis for assessment of population stratification in mitochondrial medical genetics. American Journal of Human Genetics 2010;86:904-17. PMID: 20537299; PubMed Central PMCID: PMC3032075.

July, 2010  View on PubMed  Download Article PDF 
 

CT angiography for intracerebral hemorrhage does not increase risk of acute nephropathy

CT angiography for intracerebral hemorrhage does not increase risk of acute nephropathy

Oleinik A, Romero JM, Schwab K, Lev MH, Jhawar N,  Delgado-Almondoz JE, Smith EE, Greenberg SM, Rosand J, Goldstein J. CT angiography for intracerebral hemorrhage does not increase risk of acute nephropathy. Stroke 2009; 40(7): 2393-2397. PMID: 19461032; PMCID: PMC2726774

July, 2009  View on PubMed  Download Article PDF