Diseases affecting the blood vessels of the brain, known as cerebrovascular disease, are among the leading causes of death and disability worldwide. They are responsible for strokes, gait problems, cognitive decline and depression. Research in our group combines neuroimaging and genetic analysis of individuals with stroke to elucidate the biological underpinnings of cerebrovascular disease. The group's long-term goal is to apply our discoveries to develop novel strategies that reduce the burden of cerebrovascular disease for generations to come.

We work in a highly collaborative research environment of neurologists, radiologists, imaging scientists, geneticists and computational biologists. Based in the MGH Center for Human Genetic Research, our group is fully integrated into the adjacent J. Philip Kistler Stroke Research Center and nearby Broad Institute. Lab members also work closely with investigators in the Deane Institute for Integrative Study of Atrial Fibrilation and Stroke and the Martinos Center for Biomedical Imaging. Our genetic investigations are carried out in collaboration with members of the International Stroke Genetics Consortium.